insulin-like growth factor
- insulin-like growth factor
-
IGFs I and II are polypeptides with considerable sequence similarity to insulin. They are capable of eliciting the same biological responses, including
mitogenesis in
cell culture. On the
cell surface, there are two types of IGF receptor, one of which closely resembles the
insulin receptor (which is also present). IGF I =
somatomedin A =
somatomedin C; IGF II = MSA (Multiplication-stimulating activity).
IGF-1 is released from the liver in response to growth hormone.
Dictionary of molecular biology.
2004.
Look at other dictionaries:
Insulin-like growth factor 1 — (IGF 1) that was once called somatomedin C, is a polypeptide protein hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. Production and circulationIGF … Wikipedia
Insulin-like growth factor 2 — (IGF 2) is one of three protein hormones that share structural similarity to insulin. Gene structureIn humans, the IGF2 gene is located on chromosome 11p15.5, a region which contains numerous imprinted genes. In mice this homologous region is… … Wikipedia
insulin-like growth factor 1 — wən n the juvenile form of insulin like growth factor that is produced chiefly by the liver in response to growth hormone with production declining after puberty abbr. IGF 1 … Medical dictionary
Insulin-like growth factor — The insulin like growth factors (IGFs) are polypeptides with high sequence similarity to insulin. IGFs are part of a complex system that cells use to communicate with their physiologic environment. This complex system (often referred to as the… … Wikipedia
Insulin-like growth factor — Kalottenmodell des IGF 1 nach NMR Strukturdaten.[1] Die Insulin like growth factors (IGF) (deutsch Insulinähnliche Wachstumsfaktoren) sind Polypeptide, die eine hohe Sequenzhomologie zu Insulin zeigen. Sie sind Teil ei … Deutsch Wikipedia
insulin-like growth factor — in·su·lin like growth factor .in(t) s(ə )lən .līk n either of two polypeptides structurally similar to insulin that are secreted either during fetal development or during childhood and that mediate growth hormone activity esp insulin like growth… … Medical dictionary
insulin-like growth factor — ˌ ̷ ̷ ̷ ̷ ̷ ̷ ˌ ̷ ̷ noun : either of two polypeptides structurally similar to insulin that are secreted either during fetal development or during childhood and that mediate growth hormone activity ; especially : insulin like growth factor 1 … Useful english dictionary
insulin-like growth factor 1 — noun : the juvenile form of insulin like growth factor that is produced chiefly by the liver in response to growth hormone with production declining after puberty abbreviation IGF 1 … Useful english dictionary
Insulin-like growth factor 1 receptor — The Insulin like Growth Factor 1 (IGF 1) Receptor is a transmembrane receptor that is activated by IGF 1 and by the related growth factor IGF 2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF … Wikipedia
Insulin-like growth factor 2 receptor — In biochemistry and cell biology, the insulin like growth factor 2 receptor (IGF2R), also called the cation independent mannose 6 phosphate receptor (CI MPR), is a multifunctional protein receptor that binds insulin like growth factor 2 (IGF2) at … Wikipedia
Insulin-like growth factor binding protein — The Insulin like growth factor binding protein serves as a carrier protein for Insulin like growth factor 1.Approximately 98% of IGF 1 is always bound to one of 6 binding proteins (IGF BP). IGFBP 3, the most abundant protein, accounts for 80% of… … Wikipedia
